Evaluation of Levels of Triamcinolone Acetonide in Human Perilymph and Plasma After Intratympanic Application in Patients Receiving Cochlear Implants: A Randomized Clinical Trial.

ABSTRACT:

Importance

The use of intratympanically applied steroids is of increasing interest. Consequently, research has focused on finding an ideal drug that diffuses through the round window membrane and can be retained in the perilymph.

Objective

To compare levels of triamcinolone acetonide (TAC) in perilymph and plasma after intratympanic injection.

Design, setting, and participants

This randomized clinical trial included 40 patients receiving cochlear implants at a single tertiary care center in Vienna, Austria. Patients were randomized to 1 of 4 treatment groups receiving 1 of 2 intratympanic doses of TAC (10 mg/mL or 40 mg/mL) at 1 of 2 approximate time points (24 hours or 1 hour) before sampling the perilymph. Inclusion was carried out between November 2017 and January

SUBMITTER: Dahm V 

PROVIDER: S-EPMC8485207 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature