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High prevalence of GB virus C in Brazil and molecular evidence for intrafamilial transmission.

ABSTRACT: The prevalence of GB virus C (GBV-C) in candidate Brazilian blood donors with normal and elevated alanine aminotransferase levels was found to be 5.2% (5 of 95) and 6.5% (5 of 76), respectively. Among Brazilian patients, GBV-C was found in 9.5% (13 of 137) of cases of hepatitis not caused by hepatitis A virus (HAV), HBV, HCV, HDV, or HEV (non-A-E hepatitis) and in 18.2% (8 of 44) of individuals infected with HCV. Molecular characterization of GBV-C by partial sequencing of the NS3 region showed clustering between members of a single family, implying intrafamilial transmission. In conclusion, these results together suggest that contagion mechanisms which facilitate intrafamilial transmission of GBV-C may partially explain the high prevalence of viremic carriers worldwide.

SUBMITTER: Pinho JR

PROVIDER: S-EPMC84861 | biostudies-literature | 1999 May

REPOSITORIES: biostudies-literature

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High prevalence of GB virus C in Brazil and molecular evidence for intrafamilial transmission.

Pinho J R JR Zanotto P M PM Ferreira J L JL Sumita L M LM Carrilho F J FJ da Silva L C LC Capacci M L ML Silva A O AO Guz B B Gonçales F L FL Gonçales N S NS Buck G A GA Meyers G A GA Bernardini A P AP

Journal of clinical microbiology 19990501 5

The prevalence of GB virus C (GBV-C) in candidate Brazilian blood donors with normal and elevated alanine aminotransferase levels was found to be 5.2% (5 of 95) and 6.5% (5 of 76), respectively. Among Brazilian patients, GBV-C was found in 9.5% (13 of 137) of cases of hepatitis not caused by hepatitis A virus (HAV), HBV, HCV, HDV, or HEV (non-A-E hepatitis) and in 18.2% (8 of 44) of individuals infected with HCV. Molecular characterization of GBV-C by partial sequencing of the NS3 region showed ...[more]

PMID: 10203545

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