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Molecular Evidence of Sexual Transmission of Ebola Virus.


ABSTRACT: A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in Liberia before this case. Combined with epidemiologic data, the genomic analysis provides evidence of sexual transmission of EBOV and evidence of the persistence of infective EBOV in semen for 179 days or more after the onset of EVD. (Funded by the Defense Threat Reduction Agency and others.).

SUBMITTER: Mate SE 

PROVIDER: S-EPMC4711355 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Molecular Evidence of Sexual Transmission of Ebola Virus.

Mate Suzanne E SE   Kugelman Jeffrey R JR   Nyenswah Tolbert G TG   Ladner Jason T JT   Wiley Michael R MR   Cordier-Lassalle Thierry T   Christie Athalia A   Schroth Gary P GP   Gross Stephen M SM   Davies-Wayne Gloria J GJ   Shinde Shivam A SA   Murugan Ratnesh R   Sieh Sonpon B SB   Badio Moses M   Fakoli Lawrence L   Taweh Fahn F   de Wit Emmie E   van Doremalen Neeltje N   Munster Vincent J VJ   Pettitt James J   Prieto Karla K   Humrighouse Ben W BW   Ströher Ute U   DiClaro Joseph W JW   Hensley Lisa E LE   Schoepp Randal J RJ   Safronetz David D   Fair Joseph J   Kuhn Jens H JH   Blackley David J DJ   Laney A Scott AS   Williams Desmond E DE   Lo Terrence T   Gasasira Alex A   Nichol Stuart T ST   Formenty Pierre P   Kateh Francis N FN   De Cock Kevin M KM   Bolay Fatorma F   Sanchez-Lockhart Mariano M   Palacios Gustavo G  

The New England journal of medicine 20151014 25


A suspected case of sexual transmission from a male survivor of Ebola virus disease (EVD) to his female partner (the patient in this report) occurred in Liberia in March 2015. Ebola virus (EBOV) genomes assembled from blood samples from the patient and a semen sample from the survivor were consistent with direct transmission. The genomes shared three substitutions that were absent from all other Western African EBOV sequences and that were distinct from the last documented transmission chain in  ...[more]

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