Deja-vu? Neural and behavioural effects of the 5-HT₄ receptor agonist, prucalopride, in a hippocampal-dependent memory task.

ABSTRACT: Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT₄ receptor is a promising potential treatment target for cognitive impairment because in animal studies 5-HT₄ receptor agonists enhance hippocampal-dependent memory processes. To date, there has been little work translating these effects to humans. We tested whether short-term administration of the 5-HT₄ partial agonist, prucalopride, modified behavioural and neural (fMRI) memory processing in 44 healthy human volunteers using an experimental medicine model. We found that participants who had received six days of prucalopride treatment were significantly better at recalling previously seen neutral images and distinguishing them from new

SUBMITTER: de Cates AN 

PROVIDER: S-EPMC8488034 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature