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Metastatic Urothelial Cancer: a rapidly changing treatment landscape.


ABSTRACT: Despite significant progress, metastatic urothelial cancer remains an incurable condition with a limited life expectancy. Platinum-based chemotherapy is still the mainstay of treatment for metastatic disease, but immunotherapy, antibody drug conjugates, and targeted agents have shown encouraging results in several recent practice changing trials. In this review, we discuss the standard of care, recent therapeutic advances, ongoing clinical trials, and future perspectives in metastatic urothelial carcinoma.

SUBMITTER: Stecca C 

PROVIDER: S-EPMC8488509 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Metastatic Urothelial Cancer: a rapidly changing treatment landscape.

Stecca Carlos C   Abdeljalil Osama O   Sridhar Srikala S SS  

Therapeutic advances in medical oncology 20210930


Despite significant progress, metastatic urothelial cancer remains an incurable condition with a limited life expectancy. Platinum-based chemotherapy is still the mainstay of treatment for metastatic disease, but immunotherapy, antibody drug conjugates, and targeted agents have shown encouraging results in several recent practice changing trials. In this review, we discuss the standard of care, recent therapeutic advances, ongoing clinical trials, and future perspectives in metastatic urothelial  ...[more]

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