Ontology highlight
ABSTRACT:
SUBMITTER: Ciombor KK
PROVIDER: S-EPMC9390817 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Ciombor Kristen K KK Strickler John H JH Bekaii-Saab Tanios S TS Yaeger Rona R
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20220601 24
<i>BRAF</i>-mutated advanced colorectal cancer is a relatively small but critical subset of this tumor type on the basis of prognostic and predictive implications. <i>BRAF</i> alterations in colorectal cancer are classified into three functional categories on the basis of signaling mechanisms, with the class I <i>BRAF</i><sup><i>V600E</i></sup> mutation occurring most frequently in colorectal cancer. Functional categorization of <i>BRAF</i> mutations in colorectal cancer demonstrates distinct mi ...[more]