Ontology highlight
ABSTRACT:
SUBMITTER: Lim J
PROVIDER: S-EPMC8491158 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Lim Jieyan J Chintalapudi Venkaiah V Gudmundsson Haraldur G HG Tran Minh M Bernasconi Alice A Blanco Araceli A Song Lijiang L Challis Gregory L GL Anderson Edward A EA
Organic letters 20210908 19
The stambomycins are a family of bioactive macrolides isolated from <i>Streptomyces ambofaciens</i>. Aside from two stereocenters installed through cytochrome P450 oxidations, their stereochemistry has been predicted by sequence analysis of the polyketide synthase. We report a synthesis of the C1-C27 fragment of stambomycin D, the spectroscopic data of which correlates well with that of the natural product, further validating predictive sequence analysis as a powerful tool for stereochemical ass ...[more]