Ontology highlight
ABSTRACT:
SUBMITTER: Jiang S
PROVIDER: S-EPMC8491766 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Jiang Shanya S Maphis Nicole M NM Binder Jessica J Chisholm Devon D Weston Lea L Duran Walter W Peterson Crina C Zimmerman Amber A Mandell Michael A MA Jett Stephen D SD Bigio Eileen E Geula Changiz C Mellios Nikolaos N Weick Jason P JP Rosenberg Gary A GA Latz Eicke E Heneka Michael T MT Bhaskar Kiran K
Cell reports 20210901 12
Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1β. First, RNA-sequence analysis suggests paired-helical filaments (PHFs) from human tauopathy brain primes nuclear factor κB (NF-κB), chemokine, and IL-1β signaling clusters in human primary microglia. Treating microglia with pTau-containing neuronal media, exosomes, or PHFs causes IL-1β a ...[more]