Understanding mutation hotspots for the SARS-CoV-2 spike protein using Shannon Entropy and K-means clustering.

ABSTRACT: The SARS-CoV-2 virus like many other viruses has transformed in a continual manner to give rise to new variants by means of mutations commonly through substitutions and indels. These mutations in some cases can give the virus a survival advantage making the mutants dangerous. In general, laboratory investigation must be carried to determine whether the new variants have any characteristics that can make them more lethal and contagious. Therefore, complex and time-consuming analyses are required in order to delve deeper into the exact impact of a particular mutation. The time required for these analyses makes it difficult to understand the variants of concern and thereby limiting the preventive action that can be taken against them spreading rapidly. In this analysis, we have deployed a sta

SUBMITTER: Mullick B 

PROVIDER: S-EPMC8492016 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature