Ontology highlight
ABSTRACT:
SUBMITTER: Garshick MS
PROVIDER: S-EPMC8493651 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Garshick Michael S MS Baumer Yvonne Y Dey Amit K AK Grattan Ryan R Ng Qimin Q Teague Heather L HL Yu Zu-Xi ZX Chen Marcus Y MY Tawil Michael M Barrett Tessa J TJ Underberg James J Fisher Edward A EA Krueger James J Powell-Wiley Tiffany M TM Playford Martin P MP Berger Jeffrey S JS Mehta Nehal N NN
The Journal of investigative dermatology 20200629 2
Mechanisms explaining the link between psoriasis, a proinflammatory condition, and cardiovascular disease are not fully known. PCSK9 is predominantly expressed in hepatocytes as a critical regulator of lipid metabolism, and clinical trials targeting PCSK9 reduce cardiovascular disease. Independent of its role in lipid metabolism, PCSK9 levels associate with endothelial dysfunction and predict cardiovascular events. We used two separate human psoriasis cohorts and the K14-Rac1V12<sup>-/+</sup> mu ...[more]