Ontology highlight
ABSTRACT:
SUBMITTER: Luan C
PROVIDER: S-EPMC7546417 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Luan Chao C Chen Xundi X Zhu Yun Y Osland Jared M JM Gerber Skyler D SD Dodds Melissa M Hu Yu Y Chen Min M Yuan Rong R
The Journal of investigative dermatology 20181102 4
Psoriasis is a systemic inflammatory disease, associated with metabolic disorders, including high level of low-density lipoprotein. PCSK9, which promotes the degradation of low-density lipoprotein receptors and, therefore, the increased concentration of circulating low-density lipoprotein, is also involved in inflammation. This study aims to examine the role of PCSK9 in psoriasis and to investigate the potential of topically applying small interfering RNA targeting Pcsk9 as a psoriasis treatment ...[more]