Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells.

ABSTRACT: The collective dynamics of cells on surfaces and interfaces poses technological and theoretical challenges in the study of morphogenesis, tissue engineering, and cancer. Different mechanisms are at play, including, cell-cell adhesion, cell motility, and proliferation. However, the relative importance of each one is elusive. Here, experiments with a culture of glioblastoma multiforme cells on a substrate are combined with in silico modeling to infer the rate of each mechanism. By parametrizing these rates, the time-dependence of the spatial correlation observed experimentally is reproduced. The obtained results suggest a reduction in cell-cell adhesion with the density of cells. The reason for such reduction and possible implications for the collective dynamics of cancer cells are discussed.

SUBMITTER: Melo HPM 

PROVIDER: S-EPMC8494750 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature