Dataset Information

Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study.

ABSTRACT:

Background

Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM).

Methods

From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 months in 11 hospitals in South Korea, were reviewed retrospectively. We compared glycosylated hemoglobin (HbA1c) levels before and 12 months after quadruple treatment with OHAs. The safety, maintenance rate, and therapeutic patterns after failure of the quadruple therapy were also evaluated.

Results

In total, 357 patients were enrolled for quadruple OHA therapy, and the baseline HbA1c level was 9.0%±1.3% (74.9±14.1 mmol/mol). After 12 months, 270 patients (75.6%) adhered to the quadruple therapy and HbA1c was significantly reduced from 8.9%±1.2% to 7.8%±1.3% (mean change, -1.1%±1.2%; P<0.001). The number of patients with HbA1c <7% increased significantly from 5 to 68 (P<0.005). In addition, lipid profiles and liver enzyme levels were also improved whereas no changes in body weight. There was no significant safety issue in patients treated with quadruple OHA therapy.

Conclusion

This study shows the therapeutic efficacy of the quadruple OHA regimen T2DM and demonstrates that it can be an option for the management of T2DM patients who cannot use insulin or reject injectable therapy.

SUBMITTER: Moon JS

PROVIDER: S-EPMC8497923 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study.

Moon Jun Sung JS Suh Sunghwan S Kim Sang Soo SS Jin Heung Yong HY Kim Jeong Mi JM Jang Min Hee MH Lee Kyung Ae KA Lee Ju Hyung JH Chung Seung Min SM Lyu Young Sang YS Kim Jin Hwa JH Kim Sang Yong SY Jang Jung Eun JE Kim Tae Nyun TN Kim Sung Woo SW Jeon Eonju E Cho Nan Hee NH Kim Mi-Kyung MK Kim Hye Soon HS Nam-Goong Il Seong IS Kim Eun Sook ES Chung Jin Ook JO Cho Dong-Hyeok DH Lee Chang Won CW Kim Young Il YI Chung Dong Jin DJ Won Kyu Chang KC Kim In Joo IJ Park Tae Sun TS Kim Duk Kyu DK Shon Hosang H

Diabetes & metabolism journal 20200812 5

<h4>Background</h4>Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM).<h4>Methods</h4>From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 mont ...[more]

PMID: 32794385

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Dataset Information

Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study.

Background

Methods

Results

Conclusion

Publications

Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study.

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