Ontology highlight
ABSTRACT:
SUBMITTER: Velasco-Rubio A
PROVIDER: S-EPMC8499028 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20210714 15
Benzofused seven-membered heterocycles such as 1,4-benzo[<i>e</i>]diazepines (1,4-BZDs) and 1,4-benzo[<i>e</i>]oxazepines (1,4-BZOs) were efficiently synthesized by Rh-catalyzed hydrofunctionalization of internal alkynes and allenes in good to excellent yields. The asymmetric hydroamination of (aminomethyl)anilines gave rise to 3-vinyl-1,4-BZDs with excellent enantioselectivities. Orthogonal <i>N</i>-deprotection of 1,4-BZDs allowed an easy entry to an advanced pyrrolobenzodiazepine metabolite o ...[more]