Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC8502177 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Wang Yimin Y Zhao Xiaohuan X Gao Min M Wan Xiaoling X Guo Yinong Y Qu Yingying Y Chen Yuhong Y Li Tong T Liu Haiyun H Jiang Mei M Wang Feng F Sun Xiaodong X
Cell death & disease 20211009 10
Photoreceptor death and neurodegeneration is the leading cause of irreversible vision loss. The inflammatory response of microglia plays an important role in the process of neurodegeneration. In this study, we chose retinal detachment as the model of photoreceptor degeneration. We found Myosin 1f was upregulated after retinal detachment, and it was specifically expressed in microglia. Deficiency of myosin 1f protected against photoreceptor apoptosis by inhibiting microglia activation. The elimin ...[more]