Peripheral markers of allergen-specific immune activation predict clinical allergy in eosinophilic esophagitis.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is a T-cell-mediated disease that is caused by specific foods and results in esophageal dysfunction. Existing allergy testing modalities are not helpful when attempting to identify EoE-causal foods necessitating empiric food elimination and recurrent endoscopy. The goal of this study was to identify and compare allergen-specific immune features that can be assayed in a minimally invasive manner to predict clinical food allergy in EoE.

Methods

We obtained blood samples from control subjects (n = 17), subjects with clinical EoE milk allergy (n = 17), and subjects with immunoglobulin E-mediated milk allergy (n = 9). We measured total and milk-specific plasma immunoglobulin G (IgG)4 levels and peripheral memory CD4⁺ T helper (

SUBMITTER: Dilollo J 

PROVIDER: S-EPMC8502783 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature