Unknown

Dataset Information

0

Four-Year Teriparatide Followed by Denosumab vs. Continuous Denosumab in Glucocorticoid-Induced Osteoporosis Patients With Prior Bisphosphonate Treatment.


ABSTRACT:

Objectives

In our previous 24-month study, we observed that teriparatide had some advantages over denosumab for bone mineral density (BMD) in glucocorticoid-induced osteoporosis (GIO) patients with prior bisphosphonate treatment. We conducted this extension study to investigate whether the advantage of teriparatide obtained in the first 2 years would be maintained after the switch to denosumab.

Materials and methods

We switched patients who had completed 24-month daily teriparatide treatment to denosumab (switch group, n=18) and compared their BMD every 6 months up to 48 months with the group who continued to receive denosumab (denosumab group, n=16).

Results

At 48 months, the lumbar spine BMD was significantly increased from baseline in both groups (denosumab: 10.4 ± 8.7%, p<0.001; switch: 14.2 ± 6.8%, p<0.001). However, a significant increase in femoral neck BMD from baseline occurred only in the switch group (11.2 ± 14.6%, p<0.05); denosumab (4.1 ± 10.8%). The total hip BMD increased significantly from baseline in both groups (denosumab: 4.60 ± 7.4%, p<0.05; switch: 7.2 ± 6.9%, p<0.01). Femoral neck BMD was significantly increased in the switch versus the denosumab group (p<0.05).

Conclusion

In GIO patients with prior bisphosphonate treatment, the advantage of teriparatide may be maintained after the treatment period. A continuous increase in BMD can be expected with teriparatide followed by denosumab.

SUBMITTER: Hirooka Y 

PROVIDER: S-EPMC8503555 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7352055 | biostudies-literature
| S-EPMC10834754 | biostudies-literature
| S-EPMC6785688 | biostudies-literature
| S-EPMC10286508 | biostudies-literature
| S-EPMC6139701 | biostudies-literature
| S-EPMC6619388 | biostudies-literature
| S-EPMC4880160 | biostudies-literature
| S-EPMC4083737 | biostudies-literature
| S-EPMC11301726 | biostudies-literature
| S-EPMC8252367 | biostudies-literature