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The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats.

ABSTRACT: Cardiac remodeling is a physiological adaptation to aerobic exercise and which is characterized by increases in ventricular volume and the number of cardiomyocytes. The mitochondrial derived peptide MOTS-c functions as an important regulator in physical capacity and performance. Exercise elevates levels of endogenous MOTS-c in circulation and in myocardium, while MOTS-c can significantly enhance exercise capacity. However, the effects of aerobic exercise combined with MOTS-c on cardiac structure and function are unclear. We used pressure-volume conductance catheter technique to examine cardiac function in exercised rats with and without treatment with MOTS-c. Surprisingly, MOTS-c improved myocardial mechanical efficiency, enhanced cardiac systolic function, and had a tendency to improve the diastolic function. The findings suggest that using exercise supplements could be used to modulate the cardiovascular benefits of athletic training.

SUBMITTER: Yuan J 

PROVIDER: S-EPMC8505603 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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The mitochondrial signaling peptide MOTS-c improves myocardial performance during exercise training in rats.

Yuan Jinghan J   Wang Manda M   Pan Yanrong Y   Liang Min M   Fu Yu Y   Duan Yimei Y   Tang Mi M   Laher Ismail I   Li Shunchang S  

Scientific reports 20211011 1

Cardiac remodeling is a physiological adaptation to aerobic exercise and which is characterized by increases in ventricular volume and the number of cardiomyocytes. The mitochondrial derived peptide MOTS-c functions as an important regulator in physical capacity and performance. Exercise elevates levels of endogenous MOTS-c in circulation and in myocardium, while MOTS-c can significantly enhance exercise capacity. However, the effects of aerobic exercise combined with MOTS-c on cardiac structure  ...[more]

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