Ontology highlight
ABSTRACT:
SUBMITTER: Brown CN
PROVIDER: S-EPMC8506966 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Brown Carolyn Nicole CN Cook Sarah G SG Allen Hillary F HF Crosby Kevin C KC Singh Tarjinder T Coultrap Steven J SJ Bayer K Ulrich KU
iScience 20210927 10
The Ca<sup>2+</sup>/Calmodulin-dependent protein kinase II (CaMKII) is a central regulator of synaptic plasticity and has been implicated in various neurological conditions, including schizophrenia. Here, we characterize six different CaMKIIα variants found in patients with schizophrenia. Only R396stop disrupted the 12-meric holoenzyme structure, GluN2B binding, and synaptic localization. Additionally, R396stop impaired T286 autophosphorylation that generates Ca<sup>2+</sup>-independent "autonom ...[more]