Ontology highlight
ABSTRACT:
SUBMITTER: Zhao AX
PROVIDER: S-EPMC8512572 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20211005 19
Spiro compounds provide attractive targets in drug discovery due to their inherent three-dimensional structures, which enhance protein interactions, aid solubility and facilitate molecular modelling. However, synthetic methodology for the spiro-functionalisation of important classes of penicillin and cephalosporin β-lactam antibiotics is comparatively limited. We report a novel method for the generation of spiro-cephalosporin compounds through a Michael-type addition to the dihydrothiazine ring. ...[more]