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Synthesis of Spirocyclic Piperidines by Radical Hydroarylation.


ABSTRACT: Reported here are conditions for the construction of spirocyclic piperidines from linear aryl halide precursors. These conditions employ a strongly reducing organic photoredox catalyst in combination with a trialkylamine reductant to achieve formation of aryl radical species. Regioselective cyclization followed by hydrogen-atom transfer affords a range of complex spiropiperidines. This system operates efficiently under mild conditions without the need for toxic reagents or precious metals.

SUBMITTER: Spurlin RM 

PROVIDER: S-EPMC8318207 | biostudies-literature |

REPOSITORIES: biostudies-literature

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