Self-Assembled Fibrinogen Hydro- and Aerogels with Fibrin-like 3D Structures.

ABSTRACT: The natural blood protein fibrinogen is a highly potent precursor for the production of various biomaterials due to its supreme biocompatibility and cell interaction. To gain actual materials from fibrinogen, the protein needs to undergo fibrillogenesis, which is mostly triggered via enzymatic processing to fibrin, electrospinning, or drying processes. All of those techniques, however, strongly limit the available structures or the applicability of the material. To overcome the current issues of fibrin(ogen) as material, we herein present a highly feasible, quick, and inexpensive technique for self-assembly of fibrinogen in solution into defined, nanofibrous three-dimensional (3D) patterns. Upon interaction with specific anions in controlled environments, stable and flexible hydrogel-like

SUBMITTER: Hense D 

PROVIDER: S-EPMC8512673 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature