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Biphasic electrochemical peptide synthesis† † Electronic supplementary information (ESI) available. See DOI: 10.1039/d1sc03023j


ABSTRACT: The large amount of waste derived from coupling reagents is a serious drawback of peptide synthesis from a green chemistry viewpoint. To overcome this issue, we report an electrochemical peptide synthesis in a biphasic system. Anodic oxidation of triphenylphosphine (Ph3P) generates a phosphine radical cation, which serves as the coupling reagent to activate carboxylic acids, and produces triphenylphosphine oxide (Ph3P

SUBMITTER: Nagahara S 

PROVIDER: S-EPMC8513919 | biostudies-literature |

REPOSITORIES: biostudies-literature

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