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Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C-H Functionalization Mediated by tert-Butyl Hydroperoxide.


ABSTRACT: A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-α]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the presence of a green alcohol solvent. Compared with a conventional heating system, the reaction efficiency and the rate are significantly improved and the iodine atom economy is maximized using ultrasound techniques.

SUBMITTER: Yang H 

PROVIDER: S-EPMC8515396 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Ultrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C-H Functionalization Mediated by <i>tert</i>-Butyl Hydroperoxide.

Yang Hua H   Huang Ning N   Wang Nengqing N   Shen Haicheng H   Teng Fan F   Liu Xiaoying X   Jiang Hongmei H   Tan Mei-Chen MC   Gui Qing-Wen QW  

ACS omega 20210928 40


A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-α]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the presence of a green alcohol solvent. Compared with a conventional heating system, the reaction efficiency and the rate are significantly improved and the iodine atom economy is maximized using ultrasound techniques. ...[more]

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