Crystal structure and Hirshfeld surface analysis of two imidazo[1,2-a]pyridine derivatives: N-tert-butyl-2-(4-meth-oxy-phen-yl)-5-methyl-imidazo[1,2-a]pyridin-3-amine and N-tert-butyl-2-[4-(di-methyl-amino)-phen-yl]imidazo[1,2-a]pyridin-3-amine.

ABSTRACT: In the title imidazo[1,2-a]pyridine derivatives, N-tert-butyl-2-(4-meth-oxy-phen-yl)-5-methyl-imidazo[1,2-a]pyridin-3-amine, C19H23N3O, (I), and N-tert-butyl-2-[4-(di-methyl-amino)-phen-yl]imidazo[1,2-a]pyridin-3-amine, C19H24N4, (II), the 4-meth-oxy-phenyl ring in (I) and the 4-(di-methyl-amino)-phenyl ring in (II) are inclined to the respective imidazole rings by 26.69?(9) and 31.35?(10)°. In the crystal of (I), mol-ecules are linked by N-H?N hydrogen bonds, forming chains propagating along the [001] direction. The chains are linked by C-H?? inter-actions, forming layers parallel to the (010) plane. In (II), the crystal packing also features N-H?N hydrogen bonds, which together with C-H?N hydrogen bonds link mol-ecules to form chains propagating along the c-axis direction. The chains are linked by C-H?? inter-actions to form layers parallel to the (100) plane. Inversion-related layers are linked by offset ?-? inter-actions [inter-centroid distance = 3.577?(1)?Å]. The inter-molecular inter-actions of both compounds were analyzed using Hirshfeld surface analysis and two-dimensional fingerprint plots.

SUBMITTER: Dhanalakshmi G 

PROVIDER: S-EPMC6281107 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature