TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis.

ABSTRACT: Transient receptor potential melastatin 7 (TRPM7) contributes to a variety of physiological and pathological processes in many tissues and cells. With a widespread distribution in the nervous system, TRPM7 is involved in animal behaviors and neuronal death induced by ischemia. However, the physiological role of TRPM7 in central nervous system (CNS) neuron remains unclear. Here, we identify endocytic defects in neuroendocrine cells and neurons from TRPM7 knockout (KO) mice, indicating a role of TRPM7 in synaptic vesicle endocytosis. Our experiments further pinpoint the importance of TRPM7 as an ion channel in synaptic vesicle endocytosis. Ca²⁺ imaging detects a defect in presynaptic Ca²⁺ dynamics in TRPM7 KO neuron, suggesting an importance of Ca²⁺ influx vi

SUBMITTER: Jiang ZJ 

PROVIDER: S-EPMC8516418 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature