Ontology highlight
ABSTRACT:
SUBMITTER: Sabourin LA
PROVIDER: S-EPMC85169 | biostudies-literature | 2000 Jan
REPOSITORIES: biostudies-literature
Sabourin L A LA Tamai K K Seale P P Wagner J J Rudnicki M A MA
Molecular and cellular biology 20000101 2
We have demonstrated that a novel Ste20-related kinase, designated SLK, mediates apoptosis and actin stress fiber dissolution through distinct domains generated by caspase 3 cleavage. Overexpression of SLK in C2C12 myoblasts stimulated the disassembly of actin stress fibers and focal adhesions and induced apoptosis, as determined by annexin V binding and terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling analysis. SLK was cleaved by caspase 3 in vitro and in vivo during ...[more]