Ontology highlight
ABSTRACT:
SUBMITTER: Storbeck CJ
PROVIDER: S-EPMC2754931 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Storbeck Chris J CJ Wagner Simona S O'Reilly Paul P McKay Marlene M Parks Robin J RJ Westphal Heiner H Sabourin Luc A LA
Molecular biology of the cell 20090812 19
Cell migration involves a multitude of signals that converge on cytoskeletal reorganization, essential for development, immune responses, and tissue repair. Here, we show that the microtubule-associated Ste20 kinase SLK, required for cell migration, interacts with the LIM domain binding transcriptional cofactor proteins Ldb1/CLIM2 and Ldb2/CLIM1/NLI. We demonstrate that Ldb1 and 2 bind directly to the SLK carboxy-terminal AT1-46 homology domain in vitro and in vivo. We find that Ldb1 and -2 colo ...[more]