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Elevated serum levels of methylglyoxal are associated with impaired liver function in patients with liver cirrhosis.

ABSTRACT: Methylglyoxal (MGO) is a highly reactive dicarbonyl species that forms advanced glycation end products (AGEs). The binding of these AGEs to their receptor (RAGE) causes and sustains severe inflammation. Systemic inflammation is postulated to be a major driver in the progression of liver cirrhosis. However, the role of circulating MGO levels in liver cirrhosis remains unknown. In this study, we investigated the serum levels of two dicarbonyl species, MGO and glyoxal (GO) using tandem mass spectrometry (HPLC-MS/MS) and evaluated their association with disease severity. A total of 51 inpatients and outpatients with liver cirrhosis of mixed etiology and different disease stages were included. Elevated MGO levels were seen in an advanced stage of liver cirrhosis (p < 0.001). High MGO levels remained independently associated with impaired liver function, as assessed by the model for end-stage liver disease (MELD) (β = 0.448, p = 0.002) and acute decompensation (AD) (β = 0.345, p = 0.005) scores. Furthermore, MGO was positively correlated with markers of systemic inflammation (IL-6, p = 0.004) and the development of ascites (p = 0.013). In contrast, no changes were seen in GO serum levels. Circulating levels of MGO are elevated in advanced stages of liver cirrhosis and are associated with impaired liver function and liver-related parameters.

SUBMITTER: Michel M

PROVIDER: S-EPMC8519993 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Elevated serum levels of methylglyoxal are associated with impaired liver function in patients with liver cirrhosis.

Michel Maurice M Hess Cornelius C Kaps Leonard L Kremer Wolfgang M WM Hilscher Max M Galle Peter R PR Moehler Markus M Schattenberg Jörn M JM Wörns Marcus-Alexander MA Labenz Christian C Nagel Michael M

Scientific reports 20211015 1

Methylglyoxal (MGO) is a highly reactive dicarbonyl species that forms advanced glycation end products (AGEs). The binding of these AGEs to their receptor (RAGE) causes and sustains severe inflammation. Systemic inflammation is postulated to be a major driver in the progression of liver cirrhosis. However, the role of circulating MGO levels in liver cirrhosis remains unknown. In this study, we investigated the serum levels of two dicarbonyl species, MGO and glyoxal (GO) using tandem mass spectro ...[more]

PMID: 34654829

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Elevated serum levels of methylglyoxal are associated with impaired liver function in patients with liver cirrhosis.

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Elevated serum levels of methylglyoxal are associated with impaired liver function in patients with liver cirrhosis.

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