Dataset Information

Association between dietary fat and fat subtypes with the risk of breast cancer in an Iranian population: a case-control study.

ABSTRACT:

Aim

To examine the relationship between dietary fat intake and breast cancer (BC) development.

Method

This case-control study included 473 women with breast cancer (pathologically confirmed) and 501 healthy subjects matched by age and residency. Dietary intakes of different types and sources of fatty acids were assessed using a validated food frequency questionnaire. The association between dietary fats and odds of BC was assessed using a logistic regression model in crude and multivariable-adjusted models. P values below 0.05 were regarded as statistically significant.

Results

Participants' age and body mass index were 44.0 ± 10.8 years and 28.4 ± 5.6 kg/m², respectively. Individuals with the highest quartile of total fat intake and polyunsaturated fatty acid (PUFA) intake were 1.50 times more at risk to develop BC than others. A positive significant association was observed between animal fat (Q4 vs. Q1, OR = 1.89, 95 % CI = 0.93-3.81), saturated fatty acid (SFA) (Q4 vs. Q1, OR = 1.70, 95 % CI = 0.88-3.30), monounsaturated fatty acid (MUFA) (Q4 vs. Q1 OR = 1.85, 95 % CI = 0.95-3.61) and PUFA intake (Q4 vs. Q1, OR = 2.12, 95 % CI = 1.05-4.27) with BC risk in postmenopausal women. However, there was no association in premenopausal women.

Conclusions

Total dietary fat and its subtypes might increase the risk of BC, especially in postmenopausal women. This observational study confirms the role of dietary fat in breast cancer development. Intervention studies involving different estrogen receptor subgroups are needed.

SUBMITTER: Mozafarinia M

PROVIDER: S-EPMC8520643 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Association between dietary fat and fat subtypes with the risk of breast cancer in an Iranian population: a case-control study.

Mozafarinia Maedeh M Sasanfar Bahareh B Toorang Fatemeh F Salehi-Abargouei Amin A Zendehdel Kazem K

Lipids in health and disease 20211017 1

<h4>Aim</h4>To examine the relationship between dietary fat intake and breast cancer (BC) development.<h4>Method</h4>This case-control study included 473 women with breast cancer (pathologically confirmed) and 501 healthy subjects matched by age and residency. Dietary intakes of different types and sources of fatty acids were assessed using a validated food frequency questionnaire. The association between dietary fats and odds of BC was assessed using a logistic regression model in crude and mul ...[more]

PMID: 34657612

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Project description:BackgroundDiet-based recommendations can be developed for preventing and treating non-alcoholic fatty liver disease (NAFLD) after investigating the effects of whole diets on NAFLD. The aim of this study was to identify major dietary patterns and their association with the risk of NAFLD.MethodsA total of 244 individuals (122 NAFLD patients and 122 controls) participated in this case-control study. The patients with NAFLD were diagnosed by a gastroenterologist. The participants' dietary intake data were collected using a 147-item semi-quantitive food frequency questionnaire and major dietary patterns were identified by principal component analysis. Adherence to dietary patterns was divided into tertiles and its association with odds of NAFLD was investigated by multivariate logistic regression.ResultsThe results showed four major dietary patterns, among which adherence to the "ordinary pattern" was positively associated with NAFLD risk. After adjusting for all confounding factors, individuals in the highest tertile of "ordinary pattern" exhibited a significantly elevated risk of NAFLD compared to the lowest tertile (OR?=?3.74, 95%CI?=?1.23-11.42, P trend<?0.001). As well as, Individuals in the second and third tertiles of the "traditional pattern" were associated with the risk of NAFLD compared to the lowest tertile (medium vs. lowest tertile OR?=?2.37, 95%CI?=?1.02-5.53; highest vs. lowest tertile OR?=?3.58, 95% CI?=?1.48-8.68, P trend<?0.001). The highest tertile of "vegetable and dairy pattern" compared to the lowest tertile was inversely associated with NAFLD risk (OR?=?0.23, 95%CI?=?0.09-0.58, P trend?=?0.02). No significant association was found between "fast food type pattern" and the risk of NAFLD.ConclusionA significant association was observed between different dietary patterns and the risk of NAFLD. These results can potentially serve as a dietary strategy for preventing NAFLD in individuals who are at a high risk for progression of NAFLD.

Dataset Information

Association between dietary fat and fat subtypes with the risk of breast cancer in an Iranian population: a case-control study.

Aim

Method

Results

Conclusions

Publications

Association between dietary fat and fat subtypes with the risk of breast cancer in an Iranian population: a case-control study.

Similar Datasets

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