Ontology highlight
ABSTRACT: Background
Point-of-care rapid tests to identify SARS-CoV-2 can have clinical benefits.Methods
A cross-sectional study in adults visiting emergency services or screening sites of referral hospitals for COVID-19 to validate the diagnostic performance of a rapid antigen test for SARS-CoV-2 (Abbott's Panbio) compared with reverse transcription-polymerase chain reaction (RT-PCR) testing. Tests were performed by health personnel in a routine situation during a COVID-19 outbreak.Results
A total of 1060 participants (mean age 47, 46% with a self-reported comorbidity) were recruited from 8 hospitals in Mexico. Participants provided 1060 valid Panbio rapid test-RT-PCR test pairs with 45% testing positive in the RT-PCR. Overall sensitivity of the Panbio test was 54.2% (95% CI 51%-57%), and 69.1% (95% CI 66%-73%) for patients during the first week of symptoms. Sensitivity depended on viral load (cycle threshold (Ct) of RT-PCR) and days of symptoms. With a Ct ≤25, sensitivity was 82% (95% CI, 76%-87%). Specificity of the Panbio test was >97.8% in all groups.Conclusions
The Panbio rapid antigen test for SARS-CoV-2 had good specificity but low sensitivity. A negative test requires confirmation with RT-PCR, especially for testing after the first week of symptoms.
SUBMITTER: Thirion-Romero I
PROVIDER: S-EPMC8526115 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Thirion-Romero Ireri I Guerrero-Zúñiga Dr Selene DS Arias-Mendoza Dr Alexandra DA Cornejo-Juárez Dr Dora Patricia DDP Meza-Meneses Dr Patricia DP Torres-Erazo Dr Darwin Stalin DDS Hernández-Gilsoul Dr Thierry DT Galindo-Fraga Dr Arturo DA Villegas-Mota Dr Isabel DI Sepúlveda-Delgado Dr Jesús DJ Ávila-Ríos Dr Santiago DS Becerril-Vargas Dr Eduardo DE Fernández-Plata Rosario R Pérez-Kawabe Tit Midori TM Coeto-Cano Dr Ana DA Vázquez-Pérez Dr Joel Armando DJA Kawa-Karasik Dr Simón DS Reyes-Terán Dr Gustavo DG Pérez-Padilla Dr José Rogelio DJR
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20211020
<h4>Background</h4>Point-of-care rapid tests to identify SARS-CoV-2 can have clinical benefits.<h4>Methods</h4>A cross-sectional study in adults visiting emergency services or screening sites of referral hospitals for COVID-19 to validate the diagnostic performance of a rapid antigen test for SARS-CoV-2 (Abbott's Panbio) compared with reverse transcription-polymerase chain reaction (RT-PCR) testing. Tests were performed by health personnel in a routine situation during a COVID-19 outbreak.<h4>Re ...[more]