Unknown

Dataset Information

0

Hypercalcemia as a Biomarker of Poor Prognosis in Frail Elderly Patients with COVID-19


ABSTRACT: The objective of this cohort study was to determine whether hypercalcemia in early COVID-19 was associated with 3-month mortality in frail elderly patients. Circulating calcium and albumin concentrations at hospital admission and 3-month mortality were assessed in geriatric patients hospitalized for COVID-19 with normal-to-high calcium concentrations. Hypercalcemia was defined as corrected calcium >2.5mmol/L. Covariables were age, sex, functional abilities, malignancies, hypertension, cardiomyopathy, number of acute health issues, use antibiotics and respiratory treatments. In total, 94 participants (mean±SD 88.0±5.5years; 47.9% women; 22.3% hypercalcemia; 0% hypocalcemia) were included. Sixty-five participants who survived at 3months exhibited less often hypercalcemia at baseline than the others (13.9% versus 41.4%, P=0.003). Hypercalcemia was associated with 3-month mortality (fully-adjusted HR=3.03, P=0.009) with specificity=0.86 and sensitivity=0.41. Those with hypercalcemia had shorter survival time than those with normocalcemia (log-rank P=0.002). In conclusion, hypercalcemia was associated with poorer survival in hospitalized frail elderly COVID-19 patients.

SUBMITTER: Pamart D 

PROVIDER: S-EPMC8527973 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2021-03-09 | GSE164332 | GEO
| S-EPMC7769554 | biostudies-literature
| S-EPMC9122251 | biostudies-literature
| S-EPMC7693938 | biostudies-literature
| S-EPMC7995219 | biostudies-literature
| S-EPMC9038996 | biostudies-literature
| S-EPMC7824717 | biostudies-literature
| S-EPMC8120254 | biostudies-literature
| S-EPMC6357846 | biostudies-literature
| S-EPMC9937873 | biostudies-literature