Ontology highlight
ABSTRACT:
SUBMITTER: Ahn YJ
PROVIDER: S-EPMC8534217 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Ahn Yu-Jeong YJ Shin Hyun-Joo HJ Jeong Eun-Ae EA An Hyeong-Seok HS Lee Jong-Youl JY Jang Hye-Min HM Kim Kyung-Eun KE Lee Jaewoong J Shin Meong-Cheol MC Roh Gu-Seob GS
Cells 20210924 10
Exendin-4 (Ex-4) is a glucagon-like peptide-1 receptor (GLP-1R) agonist that protects against brain injury. However, little is known about the effect of Ex-4 on kainic acid (KA)-induced seizures and hippocampal cell death. Therefore, this study evaluated the neuroprotective effects of Ex-4 pretreatment in a mouse model of KA-induced seizures. Three days before KA treatment, mice were intraperitoneally injected with Ex-4. We found that Ex-4 pretreatment reversed KA-induced reduction of GLP-1R exp ...[more]