Ontology highlight
ABSTRACT:
SUBMITTER: Nicolai MM
PROVIDER: S-EPMC8535284 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Nicolai Merle M MM Weishaupt Ann-Kathrin AK Baesler Jessica J Brinkmann Vanessa V Wellenberg Anna A Winkelbeiner Nicola N Gremme Anna A Aschner Michael M Fritz Gerhard G Schwerdtle Tanja T Bornhorst Julia J
International journal of molecular sciences 20211009 20
Although manganese (Mn) is an essential trace element, overexposure is associated with Mn-induced toxicity and neurological dysfunction. Even though Mn-induced oxidative stress is discussed extensively, neither the underlying mechanisms of the potential consequences of Mn-induced oxidative stress on DNA damage and DNA repair, nor the possibly resulting toxicity are characterized yet. In this study, we use the model organism <i>Caenorhabditis elegans</i> to investigate the mode of action of Mn to ...[more]