Dataset Information

The Sphingolipidome of the model organism Caenorhabditis elegans

ABSTRACT: Sphingolipids are important lipids and integral members of membranes, where they form small microdomains called lipid rafts. These rafts are enriched in cholesterol and sphingolipids, which influences biophysical properties. Interestingly, the membranes of the biomedical model organism Caenorhabditis elegans contain only low amounts of cholesterol. Sphingolipids in C. elegans are based on an unusual C17iso branched sphingoid base. In order to analyze and the sphingolipidome of C. elegans in more detail, we performed fractionation of lipid extracts and depletion of glycero- and glycerophospholipids together with in-depth analysis using UPLC-UHR-ToF-MS. In total we were able to detect 82 different sphingolipids from different classes, including several isomeric species.

INSTRUMENT(S): Liquid Chromatography MS - positive - reverse phase

SUBMITTER: Michael Witting

PROVIDER: MTBLS963 | MetaboLights | 2024-04-01

REPOSITORIES: MetaboLights

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Dataset's files

Source:

			Action	DRS
	MTBLS963	Other
	FILES	Other
	a_MTBLS963_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt
	i_Investigation.txt	Txt
	m_MTBLS963_LC-MS_positive_reverse-phase_metabolite_profiling_v2_maf.tsv	Tabular

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Publications

The sphingolipidome of the model organism Caenorhabditis elegans.

Hänel Victoria V Pendleton Christian C Witting Michael M

Chemistry and physics of lipids 20190424

Sphingolipids are important lipids and integral members of membranes, where they form small microdomains called lipid rafts. These rafts are enriched in cholesterol and sphingolipids, which influences biophysical properties. Interestingly, the membranes of the biomedical model organism Caenorhabditis elegans contain only low amounts of cholesterol. Sphingolipids in C. elegans are based on an unusual C17iso branched sphingoid base. In order to analyze and the sphingolipidome of C. elegans in more ...[more]

PMID: 31028715

Dataset Information

The Sphingolipidome of the model organism Caenorhabditis elegans

Dataset's files

Publications

The sphingolipidome of the model organism Caenorhabditis elegans.

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