Ontology highlight
ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC8536768 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Wu Luyan L Ishigaki Yusuke Y Zeng Wenhui W Harimoto Takashi T Yin Baoli B Chen Yinghan Y Liao Shiyi S Liu Yongchun Y Sun Yidan Y Zhang Xiaobo X Liu Ying Y Liang Yong Y Sun Pengfei P Suzuki Takanori T Song Guosheng G Fan Quli Q Ye Deju D
Nature communications 20211022 1
Tumor response to radiotherapy or ferroptosis is closely related to hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring of response to therapy, but is challenging. Here, we report the optimization of a diene electrochromic material (1-Br-Et) as a •OH-responsive chromophore, and use it to develop a near-infrared ratiometric fluorescent and photoacoustic (FL/PA) bimodal probe for in vivo imaging of •OH. The probe displays a large FL ratio ...[more]