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Cyclopeptide Derivatives from the Sponge-Derived Fungus Acremonium persicinum F10.


ABSTRACT: Cyclopeptides usually play a pivotal role, either in the viability or virulence of fungi. Two types of cyclopeptides, six new hydroxamate siderophore cyclohexapeptides (1-6), including acremonpeptides E and F, and their complexes with aluminum and ferric ions; one new cyclic pentapeptolide, aselacin D (9); together with a known compound, aselacin C (10), were isolated and characterized from the sponge-derived fungus Acremonium persicinum F10. In addition, two new siderophore analogues chelating gallium ions (Ga3+), Ga (III)-acremonpeptide E (7) and Ga (III)-acremonpeptide F (8), using isolated acremonpeptides E and F, were prepared. The planar structures of 1-10 were elucidated by HRESIMS and (1D and 2D) NMR. The absolute configurations of amino acids were determined by means of the advanced Marfey's method and X-ray single-crystal diffraction analysis. X-ray fluorescence (XRF) spectrometer was performed to disclose the elements of compound 1, indicating the existence of aluminum (Al). Al (III)-acremonpeptides E (1), Ga (III)-acremonpeptides E (5), Al (III)-acremonpeptide F (7), and Ga (III)-acremonpeptide F (8) displayed high in vitro anti-fungal activities, which are comparable to amphotericin B, against Aspergillus fumigatus and Aspergillus niger.

SUBMITTER: Li Y 

PROVIDER: S-EPMC8537450 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Cyclopeptide Derivatives from the Sponge-Derived Fungus <i>Acremonium persicinum</i> F10.

Li Yingxin Y   Li Zhiyong Z  

Marine drugs 20210924 10


Cyclopeptides usually play a pivotal role, either in the viability or virulence of fungi. Two types of cyclopeptides, six new hydroxamate siderophore cyclohexapeptides (<b>1</b>-<b>6</b>), including acremonpeptides E and F, and their complexes with aluminum and ferric ions; one new cyclic pentapeptolide, aselacin D (<b>9</b>); together with a known compound, aselacin C (<b>10</b>), were isolated and characterized from the sponge-derived fungus <i>Acremonium persicinum</i> F10. In addition, two n  ...[more]

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