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Lactones from the Sponge-Derived Fungus Talaromyces rugulosus.

ABSTRACT: The marine-derived fungus Talaromyces rugulosus isolated from the Mediterranean sponge Axinella cannabina and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (1-5), seven (3S)-resorcylide derivatives (6-12), two butenolide-resorcylide dimers (13 and 14), and three dihydroisocoumarins (15-17). Among them, fourteen compounds (1-3, 6-16) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry). TDDFT-ECD (Time-Dependent Density Functional Theory-Electronic Circular Dichroism) calculations were performed to determine the absolute configurations of chiral compounds. The butenolide-resorcylide dimers talarodilactones A and B (13 and 14) exhibited potent cytotoxicity against the L5178Y murine lymphoma cell line with IC50 values of 3.9 and 1.3 µM, respectively.

SUBMITTER: Kuppers L 

PROVIDER: S-EPMC5706048 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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The marine-derived fungus <i>Talaromyces rugulosus</i> isolated from the Mediterranean sponge <i>Axinella cannabina</i> and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (<b>1</b>-<b>5</b>), seven (3<i>S</i>)-resorcylide derivatives (<b>6</b>-<b>12</b>), two butenolide-resorcylide dimers (<b>13</b> and <b>14</b>), and three dihydroisocoumarins (<b>15</b>-<b>17</b>). Among them, fourteen compounds (<b>1</b>-<b>3</b>, <b>6</b>-<b>16</b>) are new nat  ...[more]

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