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Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System.

ABSTRACT: Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, directs expression of vancomycin-resistance genes. This review of VanRS examines how the expression of vancomycin resistance is regulated, and provides an update on one of the field's most pressing questions: How does VanS sense vancomycin?

SUBMITTER: Guffey AA

PROVIDER: S-EPMC8541618 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System.

Guffey Alexandra A AA Loll Patrick J PJ

Microorganisms 20210925 10

Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, direc ...[more]

PMID: 34683347

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