Serum Clusterin Level Could Reflect the Current Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

ABSTRACT:

Purpose

We investigated whether serum clusterin levels could reflect the current antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)-specific indices.

Materials and methods

Fifty-seven patients with AAV and 40 healthy controls were included in this study. AAV-specific indices included the Short-Form 36-Item Health Survey Physical and Mental Component Summaries (SF-36 PCS and MCS) scores, Birmingham vasculitis activity score (BVAS), five-factor score (FFS), and vasculitis damage index. Clinical and laboratory data and AAV-specific indices were obtained at blood collection. The highest tertile of BVAS (≥16) was defined as high activity of AAV.

Results

The median age of AAV patients was 64.0 years and 19 patients were male. SF-36 PCS score (r=0.328), S

SUBMITTER: Yoon T 

PROVIDER: S-EPMC8542470 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature