Browse
Submit Data
Databases
API
Help

Dataset Information

26 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Parallel transmit optimized 3D composite adiabatic spectral-spatial pulse for spectroscopy.

ABSTRACT:

Purpose

To develop a 3D composite adiabatic spectral-spatial pulse for refocusing in spin-echo spectroscopy acquisitions and to compare its performance against standard acquisition methods.

Methods

A 3D composite adiabatic pulse was designed by modulating a train of parallel transmit-optimized 2D subpulses with an adiabatic envelope. The spatial and spectral profiles were simulated and validated by experiments to demonstrate the feasibility of the design in both single and double spin-echo spectroscopy acquisitions. Phantom and in vivo studies were performed to evaluate the pulse performance and compared with semi-LASER with respect to localization performance, sequence timing, signal suppression, and specific absorption rate.

Results

Simultaneous 2D spatial localization with water and lipid suppression was achieved with the designed refocusing pulse, allowing high-quality spectra to be acquired with shorter minimum TE/TR, reduced SAR, as well as adaptation to spatially varying B₀ and B1+ field inhomogeneities in both prostate and brain studies.

Conclusion

The proposed composite pulse can serve as a more SAR efficient alternative to conventional localization methods such as semi-LASER at ultrahigh field for spin echo-based spectroscopy studies. Subpulse parallel-transmit optimization provides the flexibility to manage the tradeoff among multiple design criteria to accommodate different field strengths and applications.

SUBMITTER: He X

PROVIDER: S-EPMC8545499 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Designing parallel transmit head coil arrays based on radiofrequency pulse performance.

Project description:PurposeA new approach to design parallel transmit (pTx) head arrays is proposed that integrates transmit radiofrequency pulse designs with electromagnetic modeling of array coil elements.Theory and methodsAn approach to design pTx head arrays is proposed that finds optimal groupings of a large number of coils into a small number of channels. An algorithm is proposed to extend array-compressed parallel transmit pulse design by adding the ability to optimally select and prune coil elements, in addition to optimizing compression weights. The performance of the method is demonstrated in simulations of dynamic multislice shimming of the human brain in axial, coronal, and sagittal directions, and of reduced field-of-view excitation targeting the human occipital lobe, with simulated electromagnetic field maps from a group of 5 human head models at 7T.ResultsFor both dynamic multislice shimming and reduced field-of-view excitation, the method successfully designed pTx arrays that simultaneously achieved in general 15% lower mean excitation errors with 20% lower SDs, along with 20% lower mean global averaged specific absorption rate and 50% lower SD than previously reported pTx head array designs.ConclusionWith the proposed optimal coil element selection algorithm, the array-compressed parallel transmit pulse design can be extended to design pTx transmit head arrays with joint consideration of the fields within the sample and the radiofrequency pulse. The pTx arrays from such an approach achieved higher transmit excitation accuracy, lower radiofrequency heating in subjects, and more robust performance across subjects compared with previously reported pTx head arrays with the same number of channels.

| S-EPMC7047538 | biostudies-literature

A generalized slab-wise framework for parallel transmit multiband RF pulse design.

Project description:PurposeWe propose a new slab-wise framework to design parallel transmit multiband pulses for volumetric simultaneous multislice imaging with a large field of view along the slice direction (FOVs).Theory and methodsThe slab-wise framework divides FOVs into a few contiguous slabs and optimizes pulses for each slab. Effects of relevant design parameters including slab number and transmit B1 (B1+) mapping slice placement were investigated for human brain imaging by designing pulses with global or local SAR control based on electromagnetic simulations of a 7T head RF array. Pulse design using in vivo B1+ maps was demonstrated and evaluated with Bloch simulations.ResultsRF performance with respect to SAR reduction or B1+ homogenization across the entire human brain improved with increasing slabs; however, this improvement was nonlinear and leveled off at ∼12 slabs when the slab thickness reduced to ∼12 mm. The impact of using different slice placements for B1+ mapping was small.ConclusionCompared with slice-wise approaches where each of the many imaging slices requires both B1+ mapping and pulse optimization, the proposed slab-wise design framework attained comparable RF performance while drastically reducing the number of required pulses; therefore, it can be used to increase time efficiency for B1+ mapping, pulse calculation, and sequence preparation.

| S-EPMC4654723 | biostudies-literature

Designing 3D selective adiabatic radiofrequency pulses with single and parallel transmission.

Project description:PurposeTo introduce a method of designing single and parallel transmit (pTx) 3D adiabatic π pulses for inverting and refocusing spins that are insensitive to transmit B1 ( B1+) inhomogeneity.Theory and methodsA 3D adiabatic pulse is created by replacing each piece-wise constant element (or sub-pulse) of an adiabatic full passage (AFP) by a 2D selective pulse. In this study, the parent AFP is an HS1 and each sub-pulse is a 2D pulse derived from a jinc function designed using a spiral k-trajectory. Spatial selectivity in the third direction is achieved by blipping the slab-selective gradient between sub-pulses, yielding a rectangular slab profile identical to that of the parent AFP. The slew-rate limited sub-pulse can be undersampled utilizing pTx, thus shortening the overall pulse width. Simulations and experiments demonstrate the quality of spatial selectivity and adiabaticity achievable.ResultsThe 3D adiabatic pulse inverts and refocus spins in a sharply demarcated cylindrical volume. When stepping RF amplitude, an adiabatic threshold is observed above which the flip angle remains π. Experimental results demonstrate that pTx is an effective means to significantly improve pulse performance.ConclusionA method of designing 3D adiabatic pulses insensitive to B1 inhomogeneity has been developed. pTx can shorten these pulses while retaining their adiabatic character. Magn Reson Med 79:701-710, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

| S-EPMC5682242 | biostudies-literature

Parallel transmit pulse design for saturation homogeneity (PUSH) for magnetization transfer imaging at 7T.

Project description:PurposeThis work proposes a novel RF pulse design for parallel transmit (pTx) systems to obtain uniform saturation of semisolid magnetization for magnetization transfer (MT) contrast in the presence of transmit field B1+ inhomogeneities. The semisolid magnetization is usually modeled as being purely longitudinal, with the applied B1+ field saturating but not rotating its magnetization; thus, standard pTx pulse design methods do not apply.Theory and methodsPulse design for saturation homogeneity (PUSH) optimizes pTx RF pulses by considering uniformity of root-mean squared B1+ , B1rms , which relates to the rate of semisolid saturation. Here we considered designs consisting of a small number of spatially non-selective sub-pulses optimized over either a single 2D plane or 3D. Simulations and in vivo experiments on a 7T Terra system with an 8-TX Nova head coil in five subjects were carried out to study the homogenization of B1rms and of the MT contrast by acquiring MT ratio maps.ResultsSimulations and in vivo experiments showed up to six and two times more uniform B1rms compared to circular polarized (CP) mode for 2D and 3D optimizations, respectively. This translated into 4 and 1.25 times more uniform MT contrast, consistently for all subjects, where two sub-pulses were enough for the implementation and coil used.ConclusionThe proposed PUSH method obtains more uniform and higher MT contrast than CP mode within the same specific absorption rate (SAR) budget.

| S-EPMC9315051 | biostudies-literature

Enhanced diffusion weighting generated by selective adiabatic pulse trains.

Project description:A theoretical description and experimental validation of the enhanced diffusion weighting generated by selective adiabatic full passage (AFP) pulse trains is provided. Six phantoms (Ph-1-Ph-6) were studied on a 4 T Varian/Siemens whole body MRI system. Phantoms consisted of 2.8 cm diameter plastic tubes containing a mixture of 10 microm ORGASOL polymer beads and 2mM Gd-DTPA dissolved in 5% agar (Ph-1) or nickel(II) ammonium sulphate hexahydrate doped (56.3-0.8 mM) water solutions (Ph-2-Ph-6). A customized localization by adiabatic selective refocusing (LASER) sequence containing slice selective AFP pulse trains and pulsed diffusion gradients applied in the phase encoding direction was used to measure (1)H(2)O diffusion. The b-value associated with the LASER sequence was derived using the Bloch-Torrey equation. The apparent diffusion coefficients measured by LASER were comparable to those measured by a conventional pulsed gradient spin-echo (PGSE) sequence for all phantoms. Image signal intensity increased in Ph-1 and decreased in Ph-2-Ph-6 as AFP pulse train length increased while maintaining a constant echo-time. These experimental results suggest that such AFP pulse trains can enhance contrast between regions containing microscopic magnetic susceptibility variations and homogeneous regions in which dynamic dephasing relaxation mechanisms are dominant.

| S-EPMC2075527 | biostudies-literature

Improved bounds on Lorentz violation from composite pulse Ramsey spectroscopy in a trapped ion.

Project description:In attempts to unify the four known fundamental forces in a single quantum-consistent theory, it is suggested that Lorentz symmetry may be broken at the Planck scale. Here we search for Lorentz violation at the low-energy limit by comparing orthogonally oriented atomic orbitals in a Michelson-Morley-type experiment. We apply a robust radiofrequency composite pulse sequence in the 2F7/2 manifold of an Yb+ ion, extending the coherence time from 200 μs to more than 1 s. In this manner, we fully exploit the high intrinsic susceptibility of the 2F7/2 state and take advantage of its exceptionally long lifetime. We match the stability of the previous best Lorentz symmetry test nearly an order of magnitude faster and improve the constraints on the symmetry breaking coefficients to the 10-21 level. These results represent the most stringent test of this type of Lorentz violation. The demonstrated method can be further extended to ion Coulomb crystals.

| S-EPMC9701673 | biostudies-literature

Accelerated calibrationless parallel transmit mapping using joint transmit and receive low-rank tensor completion.

Project description:PurposeTo evaluate an algorithm for calibrationless parallel imaging to reconstruct undersampled parallel transmit field maps for the body and brain.MethodsUsing a combination of synthetic data and in vivo measurements from brain and body, 3 different approaches to a joint transmit and receive low-rank tensor completion algorithm are evaluated. These methods included: 1) virtual coils using the product of receive and transmit sensitivities, 2) joint-receiver coils that enforces a low rank structure across receive coils of all transmit modes, and 3) transmit low rank that uses a low rank structure for both receive and transmit modes simultaneously. The performance of each is investigated for different noise levels and different acceleration rates on an 8-channel parallel transmit 7 Tesla system.ResultsThe virtual coils method broke down with increasing noise levels or acceleration rates greater than 2, producing normalized RMS error greater than 0.1. The joint receiver coils method worked well up to acceleration factors of 4, beyond which the normalized RMS error exceeded 0.1. Transmit low rank enabled an eightfold acceleration, with most normalized RMS errors remaining below 0.1.ConclusionThis work demonstrates that undersampling factors of up to eightfold are feasible for transmit array mapping and can be reconstructed using calibrationless parallel imaging methods.

| S-EPMC7611890 | biostudies-literature

Local specific absorption rate (SAR), global SAR, transmitter power, and excitation accuracy trade-offs in low flip-angle parallel transmit pulse design.

Project description:We propose a constrained optimization approach for designing parallel transmit (pTx) pulses satisfying all regulatory and hardware limits. We study the trade-offs between excitation accuracy, local and global specific absorption rate (SAR), and maximum and average power for small flip-angle pTx (eight channels) spokes pulses in the torso at 3 T and in the head at 7 T.We compare the trade-offs between the above-mentioned quantities using the L-curve method. We use a primal-dual algorithm and a compressed set of local SAR matrices to design radio-frequency (RF) pulses satisfying all regulatory (including local SAR) and hardware constraints.Local SAR can be substantially reduced (factor of 2 or more) by explicitly constraining it in the pulse design process compared to constraining global SAR or pulse power alone. This often comes at the price of increased pulse power.Simultaneous control of power and SAR is needed for the design of pTx pulses that are safe and can be played on the scanner. Constraining a single quantity can create large increase in the others, which can then rise above safety or hardware limits. Simultaneous constraint of local SAR and power is fast enough to be applicable in a clinical setting.

| S-EPMC3871989 | biostudies-literature

3D UTE bicomponent imaging of cortical bone using a soft-hard composite pulse for excitation.

Project description:PurposeTo evaluate 3D UTE bicomponent imaging of cortical bone ex vivo and in vivo using a newly designed soft-hard composite pulse for excitation.MethodsChemical shift artifacts, presenting as fat-water oscillation or combination-induced signal oscillation, significantly reduce the accuracy of quantitative UTE bicomponent analysis of cortical bone. To achieve fat suppression for more reliable bicomponent analysis, a newly developed soft-hard excitation pulse was used with UTE imaging and compared with a single rectangular pulse excitation without and with a conventional fat saturation (FatSat) module. These 3 sequences were applied to 8 bovine bone samples without marrow fat, 3 bovine bone samples with marrow fat, and tibial midshafts of 5 healthy human volunteers. Bicomponent analyses were performed in both ex vivo and in vivo studies.ResultsThe soft-hard pulse provided comparable fat suppression, but much reduced bone signal attenuation compared with the FatSat module. Better bicomponent T2∗ fitting was also achieved with the soft-hard excitation pulse because it greatly reduced chemical shift artifacts and outperformed the single rectangular pulse without or with FatSat. Although the FatSat module reduced fat signals and related fat-water oscillation, the water signals were significantly attenuated with more than 40% reduction due to direction saturation. For the inner layer of tibial midshaft in healthy volunteers, fitting errors increased from 3.78% for the soft-hard pulse to 11.43% and 5.16%, respectively, for the single rectangular pulse without and with the FatSat module.ConclusionThe 3D UTE sequence with a new soft-hard excitation pulse allows more reliable bicomponent imaging of cortical bone.

| S-EPMC7924727 | biostudies-literature

Controlling radiofrequency-induced currents in guidewires using parallel transmit.

Project description:Elongated conductors, such as pacemaker leads, neurostimulator leads, and conductive guidewires used for interventional procedures can couple to the MRI radiofrequency (RF) transmit field, potentially causing dangerous tissue heating. The purpose of this study was to demonstrate the feasibility of using parallel transmit to control induced RF currents in elongated conductors, thereby reducing the RF heating hazard.Phantom experiments were performed on a four-channel parallel transmit system at 1.5T. Parallel transmit "null mode" excitations that induce minimal wire current were designed using coupling measurements derived from axial B1 (+) maps. The resulting current reduction performance was evaluated with B1 (+) maps, current sensor measurements, and fluoroptic temperature probe measurements.Null mode excitations reduced the maximum coupling mode current by factors ranging from 2 to 80. For the straight wire experiment, a current null imposed at a single wire location was sufficient to reduce tip heating below detectable levels. For longer insertion lengths and a curved geometry, imposing current nulls at two wire locations resulted in more distributed current reduction along the wire length.Parallel transmit can be used to create excitations that induce minimal RF current in elongated conductors, thereby decreasing the RF heating risk, while still allowing visualization of the surrounding volume.

| S-EPMC4470871 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data