Ontology highlight
ABSTRACT:
SUBMITTER: Lim VT
PROVIDER: S-EPMC8549822 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Lim Victoria T VT Freites J Alfredo JA Tombola Francesco F Tobias Douglas J DJ
The Journal of membrane biology 20201116 1
The voltage-gated proton channel Hv1 mediates efflux of protons from the cell. Hv1 integrally contributes to various physiological processes including pH homeostasis and the respiratory burst of phagocytes. Inhibition of Hv1 may provide therapeutic avenues for the treatment of inflammatory diseases, breast cancer, and ischemic brain damage. In this work, we investigate two prototypical Hv1 inhibitors, 2-guanidinobenzimidazole (2GBI), and 5-chloro-2-guanidinobenzimidazole (GBIC), from an experime ...[more]