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Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2.

ABSTRACT: Responding quickly to emerging respiratory viruses, such as SARS-CoV-2 the causative agent of coronavirus disease 2019 (COVID-19) pandemic, is essential to stop uncontrolled spread of these pathogens and mitigate their socio-economic impact globally. This can be achieved through drug repurposing, which tackles inherent time- and resource-consuming processes associated with conventional drug discovery and development. In this review, we examine key preclinical and clinical therapeutic and prophylactic approaches that have been applied for treatment of SARS-CoV-2 infection. We break these strategies down into virus- versus host-targeting and discuss their reported efficacy, advantages, and disadvantages. Importantly, we highlight emerging evidence on application of host serine protease-inhibiting anticoagulants, such as nafamostat mesylate, as a potentially powerful therapy to inhibit virus activation and offer cross-protection against multiple strains of coronavirus, lower inflammatory response independent of its antiviral effect, and modulate clotting problems seen in COVID-19 pneumonia.

SUBMITTER: Niemeyer BF

PROVIDER: S-EPMC8552695 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2.

Niemeyer Brian F BF Benam Kambez H KH

Pharmacology & therapeutics 20211028

Responding quickly to emerging respiratory viruses, such as SARS-CoV-2 the causative agent of coronavirus disease 2019 (COVID-19) pandemic, is essential to stop uncontrolled spread of these pathogens and mitigate their socio-economic impact globally. This can be achieved through drug repurposing, which tackles inherent time- and resource-consuming processes associated with conventional drug discovery and development. In this review, we examine key preclinical and clinical therapeutic and prophyl ...[more]

PMID: 34718070

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Dataset Information

Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2.

Publications

Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2.

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