Ontology highlight
ABSTRACT:
SUBMITTER: Feizi N
PROVIDER: S-EPMC8556378 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Feizi Neda N Focaccetti Chiara C Pacella Ilenia I Tucci Gloria G Rossi Alessandra A Costanza Massimo M Pedotti Rosetta R Sidney John J Sette Alessandro A La Rocca Claudia C Procaccini Claudio C Matarese Giuseppe G Barnaba Vincenzo V Piconese Silvia S
Cell death & disease 20211029 11
The autoimmune immunopathology occurring in multiple sclerosis (MS) is sustained by myelin-specific and -nonspecific CD8<sup>+</sup> T cells. We have previously shown that, in MS, activated T cells undergoing apoptosis induce a CD8<sup>+</sup> T cell response directed against antigens that are unveiled during the apoptotic process, namely caspase-cleaved structural proteins such as non-muscle myosin and vimentin. Here, we have explored in vivo the development and the function of the immune respo ...[more]