Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report.

ABSTRACT:

Objectives

Previous studies suggest that major depressive disorder (MDD) may be associated with volumetric indications of accelerated brain aging. This study investigated neuroanatomical signs of accelerated aging in MDD and evaluated whether a brain age gap is associated with antidepressant response.

Methods

Individuals in a major depressive episode received escitalopram treatment (10-20 mg/d) for 8 weeks. Depression severity was assessed at baseline and at weeks 8 and 16 using the Montgomery-Asberg Depression Rating Scale (MADRS). Response to treatment was characterized by a significant reduction in the MADRS (≥50%). Nonresponders received adjunctive aripiprazole treatment (2-10 mg/d) for a further 8 weeks. The brain-predicted age difference (brain-PAD) at baseline was det

SUBMITTER: Ballester PL 

PROVIDER: S-EPMC8556529 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature