Ontology highlight
ABSTRACT:
SUBMITTER: Kapustin AN
PROVIDER: S-EPMC8560811 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Kapustin Alexander N AN Davey Paul P Longmire David D Matthews Carl C Linnane Emily E Rustogi Nitin N Stavrou Maria M Devine Paul W A PWA Bond Nicholas J NJ Hanson Lyndsey L Sonzini Silvia S Revenko Alexey A MacLeod A Robert AR Ross Sarah S Chiarparin Elisabetta E Puri Sanyogitta S
Communications biology 20211101 1
Next generation modified antisense oligonucleotides (ASOs) are commercially approved new therapeutic modalities, yet poor productive uptake and endosomal entrapment in tumour cells limit their broad application. Here we compare intracellular traffic of anti KRAS antisense oligonucleotide (AZD4785) in tumour cell lines PC9 and LK2, with good and poor productive uptake, respectively. We find that the majority of AZD4785 is rapidly delivered to CD63+late endosomes (LE) in both cell lines. Important ...[more]