Ontology highlight
ABSTRACT:
SUBMITTER: Chappell AE
PROVIDER: S-EPMC7192618 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Chappell Alfred E AE Gaus Hans J HJ Berdeja Andres A Gupta Ruchi R Jo Minji M Prakash Thazha P TP Oestergaard Michael M Swayze Eric E EE Seth Punit P PP
Nucleic acids research 20200501 8
Conjugation of antisense oligonucleotide (ASO) with a variety of distinct lipophilic moieties like fatty acids and cholesterol increases ASO accumulation and activity in multiple tissues. While lipid conjugation increases tissue exposure in mice and reduces excretion of ASO in urine, histological review of skeletal and cardiac muscle indicates that the increased tissue accumulation of lipid conjugated ASO is isolated to the interstitium. Administration of palmitic acid-conjugated ASO (Palm-ASO) ...[more]