Kinetics and mechanistic investigations on antiviral drug-valacyclovir hydrochloride by heptavalent alkaline permanganate.

ABSTRACT:

Abstract

Kinetics of Permanganate (MnO₄ ^-) oxidation of antiviral drug, valacyclovir hydrochloride (VCH) has been studied spectrophotometrically at a constant ionic strength of 0.1 mol dm^-3. The reaction exhibiting a 2:1 stoichiometry (MnO₄ ^-:VCH) has been studied over a wide range of experimental conditions. It was found that the rate enhancement was associated with an increase in concentrations of alkali, reductant and temperature. A plausible mechanism involving an intermediate Mn(VII)-VCH complex (C) was expected and rate law is derived accordingly. Calculated activation parameters also supported the anticipated mechanism.

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Supplementary information

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SUBMITTER: Tuwar SM 

PROVIDER: S-EPMC8565177 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature