Kinetics and mechanistic investigations on antiviral drug-valacyclovir hydrochloride by heptavalent alkaline permanganate
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ABSTRACT: Abstract
Kinetics of Permanganate (MnO4−) oxidation of antiviral drug, valacyclovir hydrochloride (VCH) has been studied spectrophotometrically at a constant ionic strength of 0.1 mol dm−3. The reaction exhibiting a 2:1 stoichiometry (MnO4−:VCH) has been studied over a wide range of experimental conditions. It was found that the rate enhancement was associated with an increase in concentrations of alkali, reductant and temperature. A plausible mechanism involving an intermediate Mn(VII)-VCH complex (C) was expected and rate law is derived accordingly. Calculated activation parameters also supported the anticipated mechanism. Graphic abstract
Supplementary Information
The online version contains supplementary material available at 10.1007/s12039-021-01969-4.
SUBMITTER: Tuwar S
PROVIDER: S-EPMC8565177 | biostudies-literature |
REPOSITORIES: biostudies-literature
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