Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Mark Larance
LAB HEAD: Mark Larance
PROVIDER: PXD028382 | Pride | 2022-02-16
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 10 |
Byrne Stephen A SA Bedding Max J MJ Corcilius Leo L Ford Daniel J DJ Zhong Yichen Y Franck Charlotte C Larance Mark M Mackay Joel P JP Payne Richard J RJ
Chemical science 20210930 42
The modification of peptides and proteins has emerged as a powerful means to efficiently prepare high value bioconjugates for a range of applications in chemical biology and for the development of next-generation therapeutics. Herein, we report a novel method for the chemoselective late-stage modification of peptides and proteins at cysteine in aqueous buffer with suitably functionalised diaryliodonium salts, furnishing stable thioether-linked synthetic conjugates. The power of this new platform ...[more]