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[EXPERT CONSENSUS ON EFFECTIVENESS AND SAFETY OF iDPP-4 IN THE TREATMENT OF DIABETES PATIENTS AND COVID-19: EXECUTIVE SUMMARY].

ABSTRACT:

Background

This consensus aims to clarify the role of Dipeptidyl Peptidase-4 inhibitors (iDPP-4) in managing patients with diabetes during the COVID-19 pandemic.

Materials and methods

A PubMed bibliographic search was carried out (December 2019-February 2021). Oxford methodology was used for the evaluation of evidence and possible recommendations were established by consensus.

Results

Diabetes appears to be an independent factor in COVID-19 disease (evidence 2b). No increased risk of contagion with iDPP-4 is demonstrated (evidence 2b), and its use has been shown to be safe (evidence 2b). The use of this drug may present a specific benefit in reducing mortality, particularly in in-hospital use (evidence 2a), reducing admission to intensive care units (evidence 2b) and the need for mechanical ventilation (evidence 2b).

Conclusions

The use of iDPP-4 appears to be safe in patients with COVID-19, and quality studies are needed to clarify their possible advantages further.

SUBMITTER: Carrasco-Sanchez FJ

PROVIDER: S-EPMC8570981 | biostudies-literature |

REPOSITORIES: biostudies-literature

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